Floris Groenendaal Selected Research

2-iminobiotin

1/2020	Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.
10/2019	Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
2/2007	Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway.
1/2007	Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.
1/2005	Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats.
5/2004	Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig.
11/2002	Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective.
9/2002	Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia.
1/2002	Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia.

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Floris Groenendaal Research Topics

Disease

34	Asphyxia (Suffocation) 07/2022 - 05/2004
26	Hypoxia (Hypoxemia) 01/2014 - 01/2002
20	Hypothermia 01/2019 - 10/2003
20	Ischemia 01/2014 - 09/2002
15	Brain Injuries (Brain Injury) 02/2022 - 10/2005
15	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2022 - 04/2004
14	Brain Diseases (Brain Disorder) 01/2022 - 08/2010
8	Seizures (Absence Seizure) 01/2020 - 11/2004
7	Inflammation (Inflammations) 01/2022 - 01/2008
7	Hemorrhage 01/2018 - 08/2007
6	Birth Weight (Birth Weights) 01/2018 - 01/2003
5	Cerebral Palsy (Spastic Diplegia) 10/2019 - 07/2004
5	Infections 12/2014 - 12/2006
4	Sepsis (Septicemia) 01/2019 - 11/2012
4	Reperfusion Injury 05/2012 - 02/2003
3	Congenital Heart Defects (Congenital Heart Defect) 02/2022 - 11/2004
3	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 01/2013
3	Epilepsy (Aura) 10/2019 - 04/2005
3	Cardiac Arrhythmias (Arrythmia) 05/2018 - 11/2004
3	Hypotension (Low Blood Pressure) 05/2018 - 02/2006
3	Ischemic Stroke 01/2018 - 05/2010
3	Stroke (Strokes) 01/2018 - 08/2007
3	Bronchopulmonary Dysplasia 09/2013 - 02/2006
3	Lung Diseases (Lung Disease) 01/2011 - 07/2005
2	Premature Birth (Birth, Premature) 01/2022 - 01/2014
2	Necrotizing Enterocolitis 01/2021 - 05/2018
2	Critical Illness (Critically Ill) 11/2020 - 01/2016
2	Perinatal Death 01/2020 - 01/2019
2	Body Weight (Weight, Body) 01/2019 - 04/2007
2	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2019 - 01/2018
2	Coma (Comas) 01/2018 - 09/2017
2	Thrombosis (Thrombus) 01/2018 - 08/2009
2	Cysts 01/2016 - 12/2006
2	Hydrocephalus (Hydrocephaly) 07/2010 - 06/2007
2	Necrosis 12/2009 - 01/2002
2	Edema (Dropsy) 10/2003 - 09/2002
1	Intellectual Disability (Idiocy) 10/2019
1	Learning Disabilities (Learning Disability) 10/2019
1	Vision Disorders (Hemeralopia) 10/2019

Drug/Important Bio-Agent (IBA)

9	Allopurinol (Remid)FDA LinkGeneric 02/2022 - 11/2002
9	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 11/2004
9	2-iminobiotinIBA 01/2020 - 01/2002
9	Neuroprotective AgentsIBA 01/2019 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 01/2018 - 11/2002
7	Protons (Proton)IBA 01/2022 - 07/2004
7	Pharmaceutical PreparationsIBA 11/2020 - 11/2004
7	TeaIBA 01/2020 - 01/2016
7	cupric sulfide (CuS)IBA 12/2017 - 12/2006
6	Erythropoietin FDA Link 01/2018 - 11/2008
6	Hydrocortisone (Cortisol)FDA LinkGeneric 09/2013 - 07/2005
5	Lidocaine (Xylocaine)FDA LinkGeneric 01/2020 - 11/2004
5	Oxygen (Dioxygen)IBA 10/2019 - 10/2003
5	NF-kappa B (NF-kB)IBA 05/2010 - 02/2006
5	Deferoxamine (Desferal)FDA LinkGeneric 02/2009 - 11/2002
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2008 - 09/2002
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 10/2019 - 09/2002
4	Nitric Oxide Synthase (NO Synthase)IBA 01/2018 - 01/2002
4	Anti-Bacterial Agents (Antibiotics)IBA 03/2014 - 02/2009
4	Free RadicalsIBA 05/2012 - 11/2002
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2018
3	Insulin (Novolin)FDA Link 01/2019 - 01/2002
3	CytokinesIBA 07/2008 - 01/2002
3	Caspase 3 (Caspase-3)IBA 01/2008 - 01/2002
3	3-nitrotyrosineIBA 01/2008 - 01/2005
2	Blood Glucose (Blood Sugar)IBA 01/2022 - 01/2018
2	C-Reactive ProteinIBA 01/2022 - 03/2008
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 07/2005
2	Midazolam (Versed)FDA LinkGeneric 01/2019 - 01/2015
2	Nerve Growth Factors (Neurotrophins)IBA 01/2018 - 04/2016
2	CalciumIBA 04/2016 - 12/2009
2	Gentamicins (Gentamicin)FDA LinkGeneric 01/2016 - 03/2014
2	ArgonIBA 01/2015 - 01/2014
2	Dexamethasone (Maxidex)FDA LinkGeneric 09/2013 - 11/2009
2	Hypnotics and Sedatives (Sedatives)IBA 05/2012 - 02/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2009 - 01/2002
2	Neurotransmitter Agents (Neurotransmitter)IBA 03/2008 - 01/2008
2	G-Protein-Coupled Receptor Kinase 2IBA 03/2008 - 04/2004
2	Lactic Acid (Lactate)FDA LinkGeneric 07/2004 - 01/2003
2	Phosphates (Orthophosphate)IBA 05/2004 - 10/2003
2	salicylhydroxamic acid (SHAM)IBA 10/2003 - 11/2002
2	IronIBA 10/2003 - 11/2002
2	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2003 - 09/2002
1	CreatinineIBA 01/2022
1	ProcalcitoninIBA 01/2022
1	glutamyl-leucyl-valyl-isoleucyl-serine (ELVIS)IBA 01/2019
1	Morphine (MS Contin)FDA LinkGeneric 01/2019
1	GasesIBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	EnzymesIBA 05/2018
1	ElectrolytesIBA 05/2018

Therapy/Procedure

28	Induced Hypothermia 07/2022 - 02/2009
14	Therapeutics 01/2018 - 11/2004
4	Rewarming 01/2019 - 02/2009
3	Artificial Respiration (Mechanical Ventilation) 11/2016 - 04/2007
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 02/2022 - 01/2018
2	Catheters 01/2018 - 01/2003
2	Cesarean Section (Caesarean Section) 11/2012 - 07/2011
2	Extracorporeal Membrane Oxygenation 08/2010 - 02/2006
1	Ischemic Postconditioning 10/2019
1	Drug Therapy (Chemotherapy) 01/2019